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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T11908	LY2365109 hydrochloride LY2365109盐酸盐	GlyT	Neuroscience
	LY2365109 hydrochloride 是高选择性GlyT1抑制剂，抑制过表达 hGlyT1 细胞摄取谷氨酸的IC50值为 15.8 nM.
T9833	Opiranserin hydrochloride	P2X Receptor; GlyT; 5-HT Receptor	GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Opiranserin hydrochloride 是甘氨酸转运蛋白 2 型 (GlyT2) 和 5-羟色胺受体 2A (5HT2A) 的双重拮抗剂，IC50 分别为 0.86 和 1.3 μM。它显示对 rP2X3 的拮抗活性 (IC50=0.87 μM)。它正在开发为用于治疗术后疼痛的注射剂。
T6788	Bitopertin Paliflutine,比拓喷丁,RO4917838,RG1678,比托派汀	GlyT	Neuroscience
	Bitopertin (Paliflutine) 是一种有效的甘氨酸转运蛋白 1 (GlyT1) 抑制剂，对人 hGlyT1b 的 Ki 为 8.1 nM。
T16399	Opiranserin	P2X Receptor; GlyT; 5-HT Receptor	GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Opiranserin 是一种非阿片类和非 NSAID 镇痛候选药物，是 2 型甘氨酸转运蛋白 (GlyT2) 和 5-羟色胺受体 2A (5HT2A) 的双重拮抗剂，IC50分别为 0.86 和 1.3 μM。它可用于术后疼痛的研究，对 rP2X3 有拮抗作用，IC50为0.87 μM。
T21102	L-4FPG L-4-氟苯甘氨酸,L4FPG,L 4FPG	Others	Others
	L-4FPG 是甘氨酸衍生物，抑制中性氨基酸转运蛋白 ASCT1 和 ASCT2。
T37699	Org 24598
	Potent and selective inhibitor of the glial glycine transporter GlyT1b (IC50 = 6.9 nM). Displays negligible activity at GlyT-2, adrenoreceptors, dopamine, 5HT receptors and noradrenaline, dopamine, 5HT and GABA transporters (pIC50 in vivo. Chue et al (2013) Glycine reuptake inhibition as a new therapeutic approach in schizophrenia: focus on the glycine transporter 1 (GlyT1). Curr.Pharm.Des. 19 1311 PMID:23194655 \|Brown et al (2001) Discovery and SAR of org 24598-a selective glycine uptake inhibi...
T37453	Butyryl-L-carnitine (chloride)
	Butyryl-L-carnitine is a butyrate ester of carnitine. It is an inhibitor of intestinal transporters, blocking carnitine uptake by the carnitine transporter and glycine transport by the amino acid transporter in human retinal pigment epithelial (HRPE) cells (IC50s = 1.5 μM and 4.6 mM, respectively).
T70643	GT-0198 HCl
	GT-0198 is a novel glycine transporter 2 inhibitor showed activity in a mouse model of neuropathic pain. GT-0198 inhibited the function of glycine transporter 2 (GlyT2) in human GlyT2-expressing HEK293 cells and did not bind various major transporters or receptors of neurotransmitters in a competitive manner. GT-0198 is considered to be a comparatively selective GlyT2 inhibitor. GT-0198 is a structurally novel GlyT2 inhibitor bearing a phenoxymethylbenzamide moiety with in vivo efficacy in beha...

化合物

LY2365109 hydrochloride

Cat.No: T11908

Synonym: LY2365109盐酸盐

Target: GlyT

Opiranserin hydrochloride

Cat.No: T9833

Synonym:

Target: P2X Receptor, GlyT, 5-HT Receptor

Bitopertin

Cat.No: T6788

Synonym: Paliflutine,比拓喷丁,RO4917838,RG1678,比托派汀

Target: P2X Receptor, GlyT, 5-HT Receptor

L-4FPG

Cat.No: T21102

Synonym: L-4-氟苯甘氨酸,L4FPG,L 4FPG

Butyryl-L-carnitine (chloride)

Cat. No.	Product Name	Target	Signaling Pathways
T6975	Sarcosine Sarcosinic acid,Methylaminoacetic acid,Sarcosin,肌氨酸,Methylglycine,N-Methylaminoacetic acid,N-methylglycine	Others; GlyT; Endogenous Metabolite	Metabolism; Neuroscience; Others
	Sarcosine (Methylglycine) 是 I 型甘氨酸转运蛋白 (GlyT1) 的竞争性抑制剂和 N-甲基-D-天冬氨酸受体 (NMDAR) 共激动剂，通过增加甘氨酸的浓度增强 NMDA 受体的功能，可用于精神分裂症的研究。

天然产物

Sarcosine

Cat.No: T6975

Synonym: Sarcosinic acid,Methylaminoacetic acid,Sarcosin,肌氨酸,Methylglycine,N-Methylaminoacetic acid,N-methylglycine

Target: Others, GlyT, Endogenous Metabolite

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